Search results for "Extracorporeal membrane oxygenation"

showing 10 items of 21 documents

Systemic PaO2 oscillations cause mild brain injury in a pig model

2016

OBJECTIVE: Systemic PaO2 oscillations occur during cyclic recruitment and derecruitment of atelectasis in acute respiratory failure and might harm brain tissue integrity. DESIGN: Controlled animal study. SETTING: University research laboratory. SUBJECTS: Adult anesthetized pigs. INTERVENTIONS: Pigs were randomized to a control group (anesthesia and extracorporeal circulation for 20 hr with constant PaO2, n = 10) or an oscillation group (anesthesia and extracorporeal circulation for 20 hr with artificial PaO2 oscillations [3 cycles min⁻¹], n = 10). Five additional animals served as native group (n = 5). MEASUREMENTS AND MAIN RESULTS: Outcome following exposure to artificial PaO2 oscillations…

Pulmonary Atelectasismedicine.medical_specialtySwinemedicine.medical_treatment10208 Institute of NeuropathologyHippocampusInflammation610 Medicine & healthHippocampal formationReal-Time Polymerase Chain ReactionCritical Care and Intensive Care Medicinegamma-Aminobutyric acidRNA ComplementaryRandom Allocation03 medical and health sciencesExtracorporeal Membrane Oxygenation0302 clinical medicine030202 anesthesiologyNeurotransmitter receptorInternal medicinemedicineExtracorporeal membrane oxygenationAnimalsReceptoralpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acidgamma-Aminobutyric AcidRespiratory Distress Syndromebusiness.industryExtracorporeal circulationRespiration Artificialrespiratory tract diseasesEndocrinologyBrain Injuries570 Life sciences; biologyBlood Gas AnalysisInflammation Mediatorsmedicine.symptombusiness2706 Critical Care and Intensive Care Medicine030217 neurology & neurosurgerymedicine.drug
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Establishing a New ECMO Referral Center Using an ICU-Based Approach: A Feasibility and Safety Study

2022

Background: A high-volume center with a multidisciplinary team is regarded as the optimal place for providing extracorporeal membrane oxygenation (ECMO). We hypothesize that an ECMO center can also be successfully created and subsequently developed entirely by intensivists in a mid-size mixed intensive care unit (ICU). Methods: A model was created for setting up a new ECMO referral center within the structure of an existing mixed ICU in a tertiary hospital. A retrospective analysis was carried out of the first 33 patients treated in the initial period of the center’s activity, from mid 2018 to the end of 2020. Results: An ECMO center was established and developed entirely based on the resou…

surgical procedures operativeHealth Information ManagementLeadership and ManagementHealth PolicyHealth Informaticscritical care; healthcare; intensive care unit; extracorporeal membrane oxygenation; ECMOHealthcare; Volume 10; Issue 3; Pages: 414
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Evaluation of the Oxiris Membrane in Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation Support: Study Protocol for a Single Center, Sin…

2021

Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the rescue treatment proposed to patients with refractory cardiogenic shock. The VA-ECMO implantation promotes inflammation and ischemia-reperfusion injuries through the VA-ECMO flow, causing digestive mucosa barrier disrupture and inducing translocation of bacterial wall components—Lipopolysaccharides (LPS) with further inflammation and circulatory impairment. LPS is a well-studied surrogate indicator of bacterial translocation. Oxiris membrane is a promising and well-tolerated device that can specifically remove LPS. The main study aim is to compare the LPS elimination capacity of Oxiris membrane vs. a non-absorban…

medicine.medical_treatmentcontinuous renal replacement therapyheart failureoxirisContext (language use)InflammationCardiovascular Medicineartificial membranelaw.inventionStudy ProtocolRandomized controlled triallawmedicineClinical endpointExtracorporeal membrane oxygenationDiseases of the circulatory (Cardiovascular) systemRenal replacement therapycytokines/bloodbusiness.industryCardiogenic shockcardiogenic shockextracorporeal membrane oxygenationmedicine.diseasesurgical procedures operativeendotoxin/bloodRC666-701AnesthesiaHeart failuremedicine.symptomCardiology and Cardiovascular MedicinebusinessFrontiers in Cardiovascular Medicine
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A maChine and deep Learning Approach to predict pulmoNary hyperteNsIon in newbornS with congenital diaphragmatic Hernia (CLANNISH): Protocol for a re…

2021

Introduction Outcome predictions of patients with congenital diaphragmatic hernia (CDH) still have some limitations in the prenatal estimate of postnatal pulmonary hypertension (PH). We propose applying Machine Learning (ML), and Deep Learning (DL) approaches to fetuses and newborns with CDH to develop forecasting models in prenatal epoch, based on the integrated analysis of clinical data, to provide neonatal PH as the first outcome and, possibly: favorable response to fetal endoscopic tracheal occlusion (FETO), need for Extracorporeal Membrane Oxygenation (ECMO), survival to ECMO, and death. Moreover, we plan to produce a (semi)automatic fetus lung segmentation system in Magnetic Resonanc…

Pediatricsmedicine.medical_treatmentretrospective studyDiagnostic RadiologyCohort StudiesStudy ProtocolMathematical and Statistical TechniquesPregnancyMedicine and Health SciencesLung volumesMultidisciplinarymedicine.diagnostic_testRadiology and ImagingStatisticsQRSoftware EngineeringMagnetic Resonance ImagingPulmonary Imagingmachine learningObstetric ProceduresPhysical SciencesEngineering and TechnologyMedicineFemaleCohort studyComputer and Information Sciencesmedicine.medical_specialtyImaging TechniquesHypertension PulmonaryScienceSurgical and Invasive Medical ProceduresResearch and Analysis MethodsPulmonary hypertensionComputer SoftwareDiagnostic MedicineArtificial IntelligenceCongenital Diaphragmatic Hernia Pulmonary Ipertension Deep Learning protocolmedicineExtracorporeal membrane oxygenationHumansHerniaStatistical MethodsRetrospective StudiesFetal surgerybusiness.industrydiaphragmatic herniasegmentationInfant NewbornBiology and Life SciencesNeonatesCongenital diaphragmatic herniadeep learningRetrospective cohort studyMagnetic resonance imagingmedicine.diseaseSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Hernias Diaphragmatic CongenitalbusinessMathematicsDevelopmental BiologyForecasting
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Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre1…

2021

Purpose: To investigate the possible association between ventilatory settings on the first day of invasive mechanical ventilation (IMV) and mortality in patients admitted to the intensive care unit (ICU) with severe acute respiratory infection (SARI). Materials and methods: In this pre-planned sub-study of a prospective, multicentre observational study, 441 patients with SARI who received controlled IMV during the ICU stay were included in the analysis. Results: ICU and hospital mortality rates were 23.1 and 28.1%, respectively. In multivariable analysis, tidal volume and respiratory rate on the first day of IMV were not associated with an increased risk of death; however, higher driving pr…

ARDSSoins intensifs réanimationmedicine.medical_treatmentAirway pressuresPEEP positive end-expiratory pressureCritical Care and Intensive Care Medicinelaw.inventionHypoxemiaCohort StudiesPositive-Pressure RespirationMechanical ventilationSARI severe acute respiratory infectionlawHospital MortalityProspective StudiesIQR interquartile rangesProspective cohort studyRCT randomized controlled trialTidal volumeSOFA Sequential Organ Failure AssessmentSAPS Simplified Acute Physiology ScoreIntensive care unitVCV volume-controlled ventilationHIV human immunodeficiency virusIntensive Care UnitsIC GLOSSARI Intensive Care Global Study on Severe Acute Respiratory Infectionmedicine.symptomCohort studyLOS length of staymedicine.medical_specialtyVt tidal volumeCOPD Chronic obstructive pulmonary diseaseNYHA New York Heart Association.PCV pressure-controlled ventilationArticleInternal medicineICU Intensive Care UnitSIMV Synchronized intermittent mandatory ventilationmedicineTidal VolumeHumansDP driving pressurePEEPARDS acute respiratory distress syndromeMechanical ventilationbusiness.industryOdds ratioPneumoniaPlateau pressuremedicine.diseaseRespiration ArtificialVILI ventilator induced lung injuryCI confidence intervalOR odds ratioIMV invasive mechanical ventilationCPAP continuous positive airway pressureARDSbusinessSD standard deviationECMO extracorporeal membrane oxygenationPBW predicted body weightPplat plateau pressure
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Mechanical circulatory support. An expert opinion of the Association of Intensive Cardiac Care and the Association of Cardiovascular Interventions of…

2021

Mechanical circulatory support (MCS) methods are used in patients with both acute and chronic heart failure, who have exhausted other options for pharmacological or surgical treatments. The purpose of their use is to support, partially or completely, the failed ventricles and ensure adequate organ perfusion, which allows patients to restore full cardiovascular capacity, prolonging their life and effectively improving its quality. The three most popular devices include an intra-aortic balloon pump (IABP), percutaneous assist devices (including Impella, TandemHeart), and venoarterial extracorporeal membrane oxygenation (VA-ECMO). A multidisciplinary approach with the special participation of …

medicine.medical_specialtyPercutaneousmedicine.medical_treatmentShock CardiogenicPsychological interventionventilation and pharmacotherapyPercutaneous Coronary InterventionExtracorporeal membrane oxygenationHumansMedicineIntensive care medicineExpert TestimonyImpellaMechanical ventilationIntra-Aortic Balloon Pumpingbusiness.industryCardiogenic shockmechanical circulatory support-type and extensionmedicine.diseasehemodynamic and echocardiographic monitoringHeart failureConventional PCIindications and complicationsmultidisciplinary approachHeart-Assist DevicesPolandCardiology and Cardiovascular MedicinebusinessKardiologia Polska
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Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.

2020

Abstract Background Throughout the 5000-year history of China, more than 300 epidemics were recorded. Traditional Chinese herbal medicine (TCM) has been used effectively to combat each of these epidemics’ infections, and saved many lives. To date, there are hundreds of herbal TCM formulae developed for the purpose of prevention and treatment during epidemic infections. When COVID-19 ravaged the Wuhan district in China in early January 2020, without a deep understanding about the nature of COVID-19, patients admitted to the TCM Hospital in Wuhan were immediately treated with TCM and reported later with >90% efficacy. Approach We conducted conduct a systematic survey of various TCM herbal pre…

PTGS2 Prostaglandin-endoperoxide synthase 2BattleAIV avian influenza virusCoV coronavirusPharmaceutical ScienceiNOS nitric oxide synthaseViral infection0302 clinical medicinePA patchouli alcoholSARS Severe Acute Respiratory SyndromeSMD Sheganmahuang decoctionDrug DiscoveryPandemicIL InterleukinMedicine Chinese TraditionalALI acute lung injuriesmedia_commonCOVID-19 coronavirus disease 2019MXSG Ma xing shi gan decoction0303 health sciencesTNF tumor necrosis factorClinical Trials as TopicCCL2 CC chemokine ligand 2FM1 FM1 coronavirusICU intensive care unitc-AMP cyclic adenosine phosphateHIV human immunodeficiency virus030220 oncology & carcinogenesisCOX-2 cyclooxygenase-2Molecular MedicineHerbal preparationsMedicinal herbsAbbreviations: ACE2 angiotensin-converting enzyme IITCM traditional Chinese medicineHSV-1 herpes simplex virus 1CASP3 caspase 3medicine.medical_specialtyChinaCoronavirus disease 2019 (COVID-19)Systematic surveymedia_common.quotation_subjectJEV Japanese encephalitis virusNF-κB nuclear factor kappa B cellsAntiviral AgentsArticleWHO World Health Organization03 medical and health sciencesIEC-6 rat intestinal epithelial cell line 6SOD superoxide dismutaseCDC Center for Disease Control and PreventionmedicineAVP arginine vasopressinPGE2 prostaglandin E2HumansIntensive care medicineLH Lianhuaqingwen capsule030304 developmental biologyPharmacologyMedicinal herbMDA malondialdehydeGCGJ Gancao ganjiang decoctionNO nitric oxidePlants Medicinalbusiness.industrySARS-CoV-2COVID-19CXCL C-X-C- motif chemokineMDCK Madin-Darby Canine Kidney cellsTLR-4 Toll-like receptor-4COVID-19 Drug TreatmentComplementary and alternative medicineViral infectionLPS lipopolysaccharidesRSV respiratory syncytial virusQFPD Qingfeipaidu decoctionbusinessLung congestionECMO extracorporeal membrane oxygenationMAPK mitogen-activated protein kinasePhytotherapyDrugs Chinese HerbalPhytomedicine : international journal of phytotherapy and phytopharmacology
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Management of intracranial hemorrhage in adult patients on extracorporeal membrane oxygenation (ECMO): An observational cohort study.

2017

Background Intracranial hemorrhage (ICH) is a common complication in adults treated with extracorporeal membrane oxygenation (ECMO). The aim of this study was to identify predictors of outcome and investigate intervention strategies following ICH development in ECMO-treated adult patients. Methods We conducted a retrospective review of adult patients (≥18 years) who developed an ICH during ECMO treatment at the Karolinska University Hospital (Stockholm, Sweden) between September 2005 and May 2017. Outcome was assessed by 30-day mortality and Glasgow Outcome Scale (GOS) after 6 months. The statistical analysis was supplemented by a case series of patients who were surgically treated for an I…

MalePhysiologymedicine.medical_treatmentlcsh:MedicinePathology and Laboratory MedicineVascular MedicineDiagnostic RadiologyCohort Studies0302 clinical medicineAnimal CellsMedicine and Health Scienceslcsh:ScienceProspective cohort studyTomographyMultidisciplinaryGlasgow Outcome ScaleRadiology and ImagingDrugsMiddle AgedBody FluidsIntraventricular hemorrhageTreatment OutcomeBloodNeurologyAnesthesiaFemaleAnatomyCellular TypesIntracranial HemorrhagesResearch ArticleHydrocephalusAdultPlateletsSubarachnoid hemorrhageConsciousnessImaging TechniquesCognitive NeuroscienceHemorrhageNeuroimagingSurgical and Invasive Medical ProceduresPatient AdvocacyResearch and Analysis Methods03 medical and health sciencesYoung AdultExtracorporeal Membrane OxygenationSigns and SymptomsMidline shiftDiagnostic MedicinemedicineExtracorporeal membrane oxygenationHumanscardiovascular diseasesRetrospective StudiesPharmacologyBlood Cellsbusiness.industryHeparinlcsh:RBiology and Life Sciences030208 emergency & critical care medicineRetrospective cohort studyCell Biologymedicine.diseaseHydrocephalusnervous system diseasesComputed Axial TomographyHealth CareCognitive Sciencelcsh:Qbusiness030217 neurology & neurosurgeryNeurosciencePloS one
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Indications for ECMO: we need to look at the patient first

2021

2019-20 coronavirus outbreakmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)business.industryContraindicationsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MEDLINEHeartExtracorporeal Membrane OxygenationAnesthesiology and Pain MedicinemedicineHumansRespiratory InsufficiencyIntensive care medicinebusinessLungMinerva Anestesiologica
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Acute respiratory distress syndrome in traumatic brain injury: how do we manage it?

2017

Abstract: Traumatic brain injury (TBI) is an important cause of morbidity and mortality worldwide. TBI patients frequently suffer from lung complications and acute respiratory distress syndrome (ARDS), which is associated with poor clinical outcomes. Moreover, the association between TBI and ARDS in trauma patients is well recognized. Mechanical ventilation of patients with a concomitance of acute brain injury and lung injury can present significant challenges. Frequently, guidelines recommending management strategies for patients with traumatic brain injuries come into conflict with what is now considered best ventilator practice. In this review, we will explore the strategies of the best …

Pulmonary and Respiratory Medicinemedicine.medical_specialtyARDSTraumatic brain injurymedicine.medical_treatmentReview ArticleLung injury03 medical and health sciencesAcute respiratory distress syndrome (ARDS); Extra corporeal membrane oxygenation (ECMO); Positive end expiratory pressure (PEEP); Traumatic brain injury (TBI); Pulmonary and Respiratory Medicine0302 clinical medicineTraumatic brain injury (TBI); acute respiratory distress syndrome (ARDS); extra corporeal membrane oxygenation (ECMO); positive end expiratory pressure (PEEP)medicineExtracorporeal membrane oxygenationTraumatic brain injury (TBI)Intensive care medicinePositive end-expiratory pressureMechanical ventilationpositive end expiratory pressure (PEEP)Lungbusiness.industryextra corporeal membrane oxygenation (ECMO)acute respiratory distress syndrome (ARDS)030208 emergency & critical care medicinemedicine.diseaseProne positionmedicine.anatomical_structurebusiness030217 neurology & neurosurgeryJournal of thoracic disease
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